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| fmyykje | Дата: Понедельник, 02.03.2015, 14:25 | Сообщение # 1441 |
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| Daptomycin is a cyclic lipopeptide antibiotic produced through the creature Streptomyces roseosporus.[14 - [15 - Daptomycin consists of thirteen amino acids, ten of which are arranged in a cyclic fashion, and three that adorn an exocyclic tail. Two non-proteinogenic amino acids get by in the lipopeptide, the odd amino acid L-kynurenine (Kyn), but known to Daptomycin, and L-3-methylglutamic acid (mGlu). The N-terminus of the exocyclic tryptophan residue is coupled to decanoic acid, a standard limit (C10) fatty acid. Biosynthesis is initiated not later than the coupling of decanoic acid to the N-terminal tryptophan, followed by the coupling of the left over amino acids by nonribosomal peptide synthetase (NRPS) mechanisms. For all time, a cyclization event occurs, which is catalyzed through a thioesterase enzyme, and ensuing release of the lipopeptide is granted.
The non-ribosomal peptide synthetase (NRPS) liable for the coalescence of Daptomycin is encoded nearby three overlapping genes, dptA, dptBC and dptD. The dptE and dptF genes, unhesitatingly upstream of dptA, are likely to be snarled in the beginning of daptomycin biosynthesis during coupling decanoic acid to the N-terminal Trp.[16 - These best-seller genes (dptE, dptF ) be in touch to products that most able under way in conjunction with a unrivalled condensation specialization to acylate the first amino acid (tryptophan). These and other creative genes (dptI, dptJ) are believed to be complex in supplying the non-proteinogenic amino acids L-3-methylglutamic acid and Kyn; they are located next to the NRPS genes.[16 -
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| Danielki | Дата: Вторник, 03.03.2015, 22:12 | Сообщение # 1442 |
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| Danielki | Дата: Вторник, 03.03.2015, 22:24 | Сообщение # 1443 |
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| Danielki | Дата: Среда, 04.03.2015, 08:02 | Сообщение # 1444 |
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| tcsindustryr | Дата: Среда, 04.03.2015, 12:54 | Сообщение # 1445 |
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Группа: Гости
| Docetaxel (as generic or underneath the barter name Taxotere) is a clinically well-known anti-mitotic chemotherapy medication (medication which interferes with cubicle compartmentation). It is acclimated to in general payment the treatment of mamma, ovarian, prostate, and non-small chamber lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved call for as a service to treatment of patients who have locally advanced, or metastatic heart of hearts or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed[4 - and a European subscribe to for exploit in hormone-refractory prostate cancer.[5 -
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Constitution
Docetaxel is of the chemotherapy opiate bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an quotation from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Apt to dearth of paclitaxel, far-flung delving was carried peripheral exhausted leading to the formulation of docetaxel – an esterified output of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl useful group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side sequence instead of the benzyl amide in paclitaxel. The carbon 10 functioning team exchange causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a pure powder and is the effective ingredient handy in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The answer is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a only amount Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose for administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and profitable vials are combined to give a solution of 10 mg/mL and the required dispense is drawn from this solution. Vials suffer with an overfill to compensate on flowing impoverishment during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored to 24 months below 25 °C away from insight and 80 mg vials for 26 months in the same conditions.[8 -
Recently Sanofi has got authorization for one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion solution is simplified alongside eliminating the first dilution step. The two-vial and one-vial formulations in the unaltered panacea pith, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the despite the fact tranquillizer nub in the unchanged concentration as the already approved two-vial formulation. The same form, superiority, and volume of polysorbate 80 are proximate in the infusion explication of both formulations. The at best difference between these two formulations is the sum of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| Danielki | Дата: Среда, 04.03.2015, 14:19 | Сообщение # 1446 |
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| Danielki | Дата: Среда, 04.03.2015, 18:25 | Сообщение # 1447 |
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| Danielki | Дата: Четверг, 05.03.2015, 04:42 | Сообщение # 1448 |
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| Danielki | Дата: Пятница, 06.03.2015, 17:06 | Сообщение # 1449 |
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| Danielki | Дата: Воскресенье, 08.03.2015, 00:13 | Сообщение # 1450 |
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| Danielki | Дата: Воскресенье, 08.03.2015, 03:12 | Сообщение # 1451 |
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| Danielki | Дата: Воскресенье, 08.03.2015, 12:48 | Сообщение # 1452 |
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| termobrestZet | Дата: Понедельник, 09.03.2015, 01:50 | Сообщение # 1453 |
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| Danielki | Дата: Понедельник, 09.03.2015, 20:16 | Сообщение # 1454 |
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| Danielki | Дата: Четверг, 12.03.2015, 05:06 | Сообщение # 1455 |
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